Defunct but gold: Achewood; Cul de Sac; Hark! A Vagrant!; Perry Bible Fellowship (maybe still posting?)

Still putting out bangers: Nancy; Xkcd; Oglaf; Wondermark; KC Green; You’re All Just Jealous of My Jetpack

Politics: Tom the Dancing Bug; This Modern World; Kelly Comics at the Onion

Topatoco.com also has a (mostly) quality list of creators