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Cake day: June 25th, 2023

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  • Explanation: CRISPR-Cas9 is most commonly known to be a gene editor, but since its initial discovery, people have found that with some minor tweaks, CRISPR can be made to do a bunch of other things, things that biologists could have only dreamed of previously.

    If you introduce a mutation that deactivates the Cas9 protein, the entire CRISPR complex still binds to DNA. Then, you can essentially glue whatever you want onto this modified Cas9 to produce a bunch of different effects:

    • deactivated Cas9, no additional modifications: blocks other proteins from touching the DNA, which suppresses a gene without destroying it
    • glue on some transcriptional activators: makes the cell express a gene
    • glue on some fluorescent proteins: makes your DNA glow, lets you see where it is



  • Manjaro vs. SteamOS, likely no benefit. My speculation is that the company probably wanted to develop their own software but didn’t have the technical expertise to develop for Linux. Hence, they partnered with Manjaro. As for why they went with Linux in the first place, it’s likely because Windows is a mess and they likely considered that Linux would be a more marketable (and cheaper) operating system.

    And yes, these products aren’t particularly expanding the market, but it seems that companies would still like to throw their hat into the ring, if only because getting in early means that they’ll have a more dedicated fanbase for their later handheld products




  • Heavily context dependent, I’d say. In a vacuum, it’s not that unusual. The entire purpose of text is that you don’t have to respond immediately. If it happens constantly, then maybe it would have been worth figuring out why that keeps happening. Maybe he dislikes you, or maybe he’s just busy.

    It seems you already understand that, though. So perhaps the more informative question is why you feel the way that you feel towards your ex. Frankly, it’s probably some level of infatuation (or as I call it, puppy love). It’s not intrinsically bad, but it does tend to drive people to have unrealistic expectations for their partners, which can drive conflict once those expectations become established


  • You can blindly download and install things from the internet on Windows, you can’t in Linux. If you try, it’ll be confusing at best, destructive at worst. If you want to install something, best to look for it in your GUI software manager (the “app store”)

    If you’re up for the challenge (it’s extremely tedious to set up, partially thanks to its horrid instructions), you can try installing winapps. It’ll save you a lot of time with running Windows programs



  • Sure, but the overall intent holds true. Not just in professional settings, it’s important to have the skill to reframe a negative comment into a positive one.

    This is probably what I would say:

    It sounds like you’ve got everything you need for the meeting. Would it still make sense for me to attend?

    If that’s the case, then I think I’d be more useful handling some other tasks in the meantime. Please keep me updated on the outcome of the meeting